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Infant Leukemia

MedGen UID:
885468
•Concept ID:
C4054726
•
Neoplastic Process
Synonym: Leukemia in Infancy

Definition

An acute lymphoblastic or acute myeloid leukemia that occurs in infancy. [from NCI]

Professional guidelines

PubMed

Treatment of infant leukemias: challenge and promise.
Brown P
Hematology Am Soc Hematol Educ Program 2013;2013:596-600. doi: 10.1182/asheducation-2013.1.596. PMID: 24319237Free PMC Article
Clinical features, molecular diagnosis, and treatment outcome of infants with leukemia in Taiwan.
Chen SH, Yang CP, Hung IJ, Jaing TH, Shih LY, Tsai MH
Pediatr Blood Cancer 2010 Dec 15;55(7):1264-71. doi: 10.1002/pbc.22731. PMID: 20979094
Treatment of infant leukemia with busulfan, cyclophosphamide +/- etoposide and bone marrow transplantation.
Emminger W, Emminger-Schmidmeier W, Haas OA, Urban C, Ambros P, Peters C, Mann G, Fink FM, Ferstl G, Höcker P
Bone Marrow Transplant 1992 May;9(5):313-8. PMID: 1617314

Recent clinical studies

Etiology

Pediatric leukemia and maternal occupational exposure to anticancer drugs: the Japan Environment and Children's Study.
Yamamoto S, Sanefuji M, Suzuki M, Sonoda Y, Hamada N, Kato W, Ono H, Oba U, Nakashima K, Ochiai M, Kusuhara K, Koga Y, Ohga S
Blood 2024 Jan 25;143(4):311-319. doi: 10.1182/blood.2023021008. PMID: 37788408
Exposure to pesticides and childhood leukemia risk: A systematic review and meta-analysis.
Karalexi MA, Tagkas CF, Markozannes G, Tseretopoulou X, Hernández AF, Schüz J, Halldorsson TI, Psaltopoulou T, Petridou ET, Tzoulaki I, Ntzani EE
Environ Pollut 2021 Sep 15;285:117376. Epub 2021 May 18 doi: 10.1016/j.envpol.2021.117376. PMID: 34380208
Cytogenetics of Pediatric Acute Myeloid Leukemia: A Review of the Current Knowledge.
Quessada J, Cuccuini W, Saultier P, Loosveld M, Harrison CJ, Lafage-Pochitaloff M
Genes (Basel) 2021 Jun 17;12(6) doi: 10.3390/genes12060924. PMID: 34204358Free PMC Article
Acute Leukemia in Infants.
Ibrahimova A, Pommert L, Breese EH
Curr Oncol Rep 2021 Feb 12;23(3):27. doi: 10.1007/s11912-021-01021-1. PMID: 33580326
Parental alcohol consumption and risk of leukemia in the offspring: a systematic review and meta-analysis.
Karalexi MA, Dessypris N, Thomopoulos TP, Ntouvelis E, Kantzanou M, Diamantaras AA, Moschovi M, Baka M, Hatzipantelis E, Kourti M, Polychronopoulou S, Stiakaki E, Mora AM, Wunsch-Filho V, Infante-Rivard C, Loutradis D, Petridou ET
Eur J Cancer Prev 2017 Sep;26(5):433-441. doi: 10.1097/CEJ.0000000000000350. PMID: 28379884

Diagnosis

Pediatric leukemia and maternal occupational exposure to anticancer drugs: the Japan Environment and Children's Study.
Yamamoto S, Sanefuji M, Suzuki M, Sonoda Y, Hamada N, Kato W, Ono H, Oba U, Nakashima K, Ochiai M, Kusuhara K, Koga Y, Ohga S
Blood 2024 Jan 25;143(4):311-319. doi: 10.1182/blood.2023021008. PMID: 37788408
Cytogenetics of Pediatric Acute Myeloid Leukemia: A Review of the Current Knowledge.
Quessada J, Cuccuini W, Saultier P, Loosveld M, Harrison CJ, Lafage-Pochitaloff M
Genes (Basel) 2021 Jun 17;12(6) doi: 10.3390/genes12060924. PMID: 34204358Free PMC Article
Acute Leukemia in Infants.
Ibrahimova A, Pommert L, Breese EH
Curr Oncol Rep 2021 Feb 12;23(3):27. doi: 10.1007/s11912-021-01021-1. PMID: 33580326
Early-age Acute Leukemia: Revisiting Two Decades of the Brazilian Collaborative Study Group.
Pombo-de-Oliveira MS, Andrade FG; Brazilian Collaborative Study Group of Infant Acute Leukaemia
Arch Med Res 2016 Nov;47(8):593-606. doi: 10.1016/j.arcmed.2016.11.014. PMID: 28476187
Pediatric acute lymphoblastic leukemia.
Carroll WL, Bhojwani D, Min DJ, Raetz E, Relling M, Davies S, Downing JR, Willman CL, Reed JC
Hematology Am Soc Hematol Educ Program 2003:102-31. doi: 10.1182/asheducation-2003.1.102. PMID: 14633779

Therapy

Pediatric leukemia and maternal occupational exposure to anticancer drugs: the Japan Environment and Children's Study.
Yamamoto S, Sanefuji M, Suzuki M, Sonoda Y, Hamada N, Kato W, Ono H, Oba U, Nakashima K, Ochiai M, Kusuhara K, Koga Y, Ohga S
Blood 2024 Jan 25;143(4):311-319. doi: 10.1182/blood.2023021008. PMID: 37788408
Exposure to pesticides and childhood leukemia risk: A systematic review and meta-analysis.
Karalexi MA, Tagkas CF, Markozannes G, Tseretopoulou X, Hernández AF, Schüz J, Halldorsson TI, Psaltopoulou T, Petridou ET, Tzoulaki I, Ntzani EE
Environ Pollut 2021 Sep 15;285:117376. Epub 2021 May 18 doi: 10.1016/j.envpol.2021.117376. PMID: 34380208
Acute Leukemia in Infants.
Ibrahimova A, Pommert L, Breese EH
Curr Oncol Rep 2021 Feb 12;23(3):27. doi: 10.1007/s11912-021-01021-1. PMID: 33580326
Parental alcohol consumption and risk of leukemia in the offspring: a systematic review and meta-analysis.
Karalexi MA, Dessypris N, Thomopoulos TP, Ntouvelis E, Kantzanou M, Diamantaras AA, Moschovi M, Baka M, Hatzipantelis E, Kourti M, Polychronopoulou S, Stiakaki E, Mora AM, Wunsch-Filho V, Infante-Rivard C, Loutradis D, Petridou ET
Eur J Cancer Prev 2017 Sep;26(5):433-441. doi: 10.1097/CEJ.0000000000000350. PMID: 28379884
The ABCs of infant leukemia.
Zweidler-McKay PA, Hilden JM
Curr Probl Pediatr Adolesc Health Care 2008 Mar;38(3):78-94. doi: 10.1016/j.cppeds.2007.12.001. PMID: 18279790

Prognosis

Cytogenetics of Pediatric Acute Myeloid Leukemia: A Review of the Current Knowledge.
Quessada J, Cuccuini W, Saultier P, Loosveld M, Harrison CJ, Lafage-Pochitaloff M
Genes (Basel) 2021 Jun 17;12(6) doi: 10.3390/genes12060924. PMID: 34204358Free PMC Article
Parental alcohol consumption and risk of leukemia in the offspring: a systematic review and meta-analysis.
Karalexi MA, Dessypris N, Thomopoulos TP, Ntouvelis E, Kantzanou M, Diamantaras AA, Moschovi M, Baka M, Hatzipantelis E, Kourti M, Polychronopoulou S, Stiakaki E, Mora AM, Wunsch-Filho V, Infante-Rivard C, Loutradis D, Petridou ET
Eur J Cancer Prev 2017 Sep;26(5):433-441. doi: 10.1097/CEJ.0000000000000350. PMID: 28379884
MLL1/WDR5 complex in leukemogenesis and epigenetic regulation.
Wu M, Shu HB
Chin J Cancer 2011 Apr;30(4):240-6. doi: 10.5732/cjc.011.10055. PMID: 21439245Free PMC Article
MLL fusions: pathways to leukemia.
Liu H, Cheng EH, Hsieh JJ
Cancer Biol Ther 2009 Jul;8(13):1204-11. doi: 10.4161/cbt.8.13.8924. PMID: 19729989Free PMC Article
Pediatric acute lymphoblastic leukemia.
Carroll WL, Bhojwani D, Min DJ, Raetz E, Relling M, Davies S, Downing JR, Willman CL, Reed JC
Hematology Am Soc Hematol Educ Program 2003:102-31. doi: 10.1182/asheducation-2003.1.102. PMID: 14633779

Clinical prediction guides

Exposure to pesticides and childhood leukemia risk: A systematic review and meta-analysis.
Karalexi MA, Tagkas CF, Markozannes G, Tseretopoulou X, Hernández AF, Schüz J, Halldorsson TI, Psaltopoulou T, Petridou ET, Tzoulaki I, Ntzani EE
Environ Pollut 2021 Sep 15;285:117376. Epub 2021 May 18 doi: 10.1016/j.envpol.2021.117376. PMID: 34380208
Cesarean Delivery and Risk of Infant Leukemia: A Report from the Children's Oncology Group.
Marcotte EL, Richardson MR, Roesler MA, Spector LG
Cancer Epidemiol Biomarkers Prev 2018 Apr;27(4):473-478. Epub 2018 Jan 22 doi: 10.1158/1055-9965.EPI-17-0778. PMID: 29358226Free PMC Article
Parental alcohol consumption and risk of leukemia in the offspring: a systematic review and meta-analysis.
Karalexi MA, Dessypris N, Thomopoulos TP, Ntouvelis E, Kantzanou M, Diamantaras AA, Moschovi M, Baka M, Hatzipantelis E, Kourti M, Polychronopoulou S, Stiakaki E, Mora AM, Wunsch-Filho V, Infante-Rivard C, Loutradis D, Petridou ET
Eur J Cancer Prev 2017 Sep;26(5):433-441. doi: 10.1097/CEJ.0000000000000350. PMID: 28379884
Early-age Acute Leukemia: Revisiting Two Decades of the Brazilian Collaborative Study Group.
Pombo-de-Oliveira MS, Andrade FG; Brazilian Collaborative Study Group of Infant Acute Leukaemia
Arch Med Res 2016 Nov;47(8):593-606. doi: 10.1016/j.arcmed.2016.11.014. PMID: 28476187
Pediatric acute lymphoblastic leukemia.
Carroll WL, Bhojwani D, Min DJ, Raetz E, Relling M, Davies S, Downing JR, Willman CL, Reed JC
Hematology Am Soc Hematol Educ Program 2003:102-31. doi: 10.1182/asheducation-2003.1.102. PMID: 14633779

Recent systematic reviews

Exposure to pesticides and childhood leukemia risk: A systematic review and meta-analysis.
Karalexi MA, Tagkas CF, Markozannes G, Tseretopoulou X, Hernández AF, Schüz J, Halldorsson TI, Psaltopoulou T, Petridou ET, Tzoulaki I, Ntzani EE
Environ Pollut 2021 Sep 15;285:117376. Epub 2021 May 18 doi: 10.1016/j.envpol.2021.117376. PMID: 34380208
Parental alcohol consumption and risk of leukemia in the offspring: a systematic review and meta-analysis.
Karalexi MA, Dessypris N, Thomopoulos TP, Ntouvelis E, Kantzanou M, Diamantaras AA, Moschovi M, Baka M, Hatzipantelis E, Kourti M, Polychronopoulou S, Stiakaki E, Mora AM, Wunsch-Filho V, Infante-Rivard C, Loutradis D, Petridou ET
Eur J Cancer Prev 2017 Sep;26(5):433-441. doi: 10.1097/CEJ.0000000000000350. PMID: 28379884

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